Antibiotics and synthetic hormones are emerging contaminants that can accumulate and biomagnify through marine food webs, posing a potential risk to ecosystem health and the safety of fisheries and aquaculture products. BIOACUMAR will assess the presence of residues of these compounds, as well as antimicrobial-resistant bacteria, in the marine food web of the Asturian and Andalusian coasts using bioindicator species such as European seabass (wild and farmed), small-spotted catshark and bottlenose dolphin.The project will investigate the possible origin of these contaminants (human, livestock or aquaculture-related sources) and evaluate the associated environmental and health risks. The results will provide key information to support sustainable fisheries and aquaculture practices, particularly within Natura 2000 sites, while contributing to food safety and ecosystem conservation through a One Health approach.BIOACUMAR will also promote knowledge transfer towards public administrations and the fisheries and aquaculture sectors, providing scientific evidence to support environmental planning, management and decision-making.